Pharmacophore, third unit of CAAD B.Pharmacy 8th Semester 2019 (2018-2019) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

Pharmacophore Modelling

Virtual screening

Types of virtual screening - Ligad based and Structure based

Pharmacophore

Pharmacophore Mapping - Definition, Steps

Pharmacophore based screening and its steps

Analogue based drug design

1. Goals of analogue design
2. Categories of analogues

Bioisosterism and its classification

Bioisosteric replacement

1. Classical 

1. Bioisosterism of monovalent atoms or groups

• • Interchange of hydrogen with fluorine
  • Interchange of hydroxyl and amino group
  • Interchange of thiole-hydroxy group

     b. Bioisosterism of divalent atoms or groups

     c. Interchange of trivalent atoms or groups

2. Non-classical bioisosteric replacement

•  Non classical bioisosteric replacement of functional groups