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Pharmaceutics I

BPharmacy, 1st Semester, 2017 - Question Paper

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Pharmaceutics I BPharmacy 1st semester 2017 Previous Year's Question Papers/Notes Download - HK Technical PGIMS

Roll No....................... Dec, 2017/103S17 (B. Pharmacy 1st Semester-2017) PHARMACEUTICS-I Time: Three hours M. Marks: 75 Note: Do not write anything except roll no. on this question paper Section-A Multiple Choice Questions- Attempt all questions Q.1 (a) The dose for 12yr old child if adult dose is 100mg as per Young’s formula would be: 20x1=20 (i) 100mg (ii) 50mg (iii) 75mg (iv) 25mg (b) The part of prescription which gives dispensing instruction to pharmacist is: (i) Superscription (ii) Inscription (iii) Subscription (iv) Signatura (c) The powder which liquefy on mixing are called as: (i) Eutectic mixtures (ii) Efflorescent mixtures (iii) Hygroscopic (iv) Dusting (d) The application of determining proof strength of spirit is to calculate _____ (i) Solubility (ii) Excise duty (iii) Flammability (iv) None of the above (e) Enemas are used for: (i) Systemic delivery (ii) Rectal delivery (iii) Clean bowel (iv) All of the above (f) The Oil: Water: Gum used in wet gum method of preparation of liquid paraffin emulsion: (i) 4:2:1 (ii) 3:2:1 (iii) 2:2:1 (iv) None of these (g) The incompatibility arising out of prescribing together of Diazepam and Caffeine is: (i) Physical (ii) Chemical (iii) Therapeutic (iv) Both (i)& (ii) (h) The suppositories can be used for: (i) Nasal delivery (ii) vaginal delivery (iii) rectal delivery (iv) All of these (i) Identify the emulsion dosage form: (i) Ointment (ii) Cream (iii) Poultice (iv) Gels (j) Identify the humectant from the followings: (i) Alcohol (ii) Glycerol (iii) Liquid paraffin (iv) Chlorocresol (k) Which of the following method would be used for dispensing of peppermint oil emulsion? (i) Dry gum method (ii) Wet gum method (iii) Bottle method (iv) All of these (l) Identify the sweetening agent for use in oral solutions meant for diabetic patients: (i) Sucrose (ii) Fructose (iii) Sorbitol (iv) Aspartame (m) How many grams of boric acid are required to prepare 2 fluid ounce of 2% w/v solution? (i) 2gm (ii) 1.2gm (iii) 2.4gm (iv) 4gm (n) A prescription instructs Cap. Ampicillin 250mg QID. The patient will take one cap___ (i) Every 4th hr. (ii) 3 times a day (iii) 4 times a day (iv) Once a day (o) Which of the following can be used as isotonic modifiers in eye drops? (i) Dextrose (ii) Sodium Chloride (iii) Boric Acid (iv) All of the above (p) Which of the following solutions of sodium chloride will cause haemolysis of RBC’s? (i) 0.9% w/v (ii) 0.35% w/v (iii) 1.5% w/v (iv) 2% w/v (q) Identify the base which cannot be used in eye ointments: (i) Yellow bees wax (ii) White bees wax (iii) Wool fat (iv) Hard paraffin (r) One dessertspoonful corresponds to ______mL: (i) 4 (ii) 10 (iii) 15 (iv) 20 (s) What is the optimal pH for nasal solution? (i) 6.5 (ii) 3.5 (iii) 7.5 (iv) 8.5 (t) Identify the formulation with labelling instruction to apply gently without rubbing: (i) Liniments (ii) Lotions (iii) Paste (iv) Gels Section-B Long answer type questions. Answer any 2 questions. Q.2 Define and classify suspensions. What is the difference between flocculated and deflocculated suspension. 10 Discuss the stability problems in suspensions and method to overcome them. Q.3 identify the incompatibility mechanism an give method of correction and dispensing of the following 10 prescription: Rx Sodium bicarbonate....3.0g Rx Quinine Sulphate...10g Borax.............................3.0g Dil sulphuric acid...20ml Glycerine.......50g Potassium iodide....3g Water upto ..... 100g Water upto...200ml Make a nasal spray Make a mixture Q.4 (a) How much sodium chloride would be required to make 0.4%(w/v) Ephedrine hydrochloride solution isotonic to nasal secretions? (Given that the freezing point of 1%(w/v) solution of Ephedrine HCl is 0.169degree C & of 1%9w/v) sodium chloride solution is 0.576degree C). (b) in what proportion should the ZnO ointments of strength 20% (w/w), 18%(w/w) and 50%(w/w) be mixed to prepare 28%(w/w) alcohol? (c) Calculate the dose of cefadroxil for a child of age 6 years and infant of age 9 months if the daily adult dose of cefadroxil 1gm. 10 Section-C Short answer type questions, Answer any 7 questions Q.5 Explain various tests used for identification of emulsion type. 5 Q.6 Explain creaming, cracking, phase inversion. Give methods to overcome these problems. 5 Q.7 Differentiate between (a) Gargle & Mouth washes (b) Ointments & creams 5 Q.8 Explain the various factors influencing dermal penetration of drugs. 5 Q.9 Write an account on Indian Pharmacopoeia. 5 Q.10 Write a note on Ear drops. 5 Q.11 What are simple & compound powders? Explain geometric dilutions. 5 Q.12 Define suppositories. Give their advantages, disadvantages and uses. 5 Q.13 Write an account on solubility enhancement techniques. 5

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