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Unit-1 Preformulation Studies Formulative (Industrial) Pharmacy Handwritten Notes 5th Semester B.Pharmacy Lecture Notes,BP502T Formulative (Industrial) Pharmacy,BPharmacy,Handwritten Notes,Formulative Pharmacy,BP502T,BPharm 5th Semester,Industrial Pharmacy,

Unit-1 Preformulation Studies Formulative (Industrial) Pharmacy Handwritten Notes

B.Pharmacy, 5th Semester, 2022 (2021-2022) - Lecture Notes

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Unit-1 Preformulation Studies Formulative (Industrial) Pharmacy Handwritten Notes

UNIT-I

Preformulation Studies: Introduction to preformulation, goals and objectives, study of
physicochemical characteristics of drug substances.

a. Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism

b. Chemical Properties: Hydrolysis, oxidation, reduction, racemisation, polymerization
BCS classification of drugs

Application of preformulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.

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