Proton Pump Inhibitors (PPIs): Mechanism, Uses & Side Effects in Acid-Related Disorders B.Pharmacy 5th Semester 2025 (2024-2025) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

Proton pump inhibitors (PPIs), the gold standard for gastric acid suppression, with this concise guide covering:

• Mechanism: Irreversible inhibition of H+/K+H+/K+ ATPase ("proton pump") via covalent binding to cysteine residues.

• Clinical Uses:

  • GERD (gastroesophageal reflux disease)

  • Peptic ulcers (including H. pylori eradication)

  • Zollinger-Ellison syndrome

  • Prevention of NSAID-induced gastric bleeding

• Side Effects: Constipation, dizziness, headaches, and potential long-term risks (e.g., nutrient malabsorption).

• Advantage Over H2H2​-Blockers: Superior acid suppression with prolonged action.

Key Highlights:

• Structure-Activity: Substituted benzimidazole + pyridine rings enable acid-activated drug targeting.

• Therapeutic Impact: PPIs revolutionized GERD/ulcer management but require cautious long-term use.

• Side Effect Mnemonic: "CD-HIT" (Constipation, Dizziness, Headaches, Infections, Taste changes).