Pharmacology III unit 4 PART 2 B.Pharmacy 6th Semester 2024 (2023-2024) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

Chemotherapy of Malignancy

Introduction

Types of Cancer

• Carcinomas
• Sarcomas
• Leukemias
• Multiple Myeloma
• Lymphomas
• CNS tumors
• Melanoma
• Germ Cell Tumor
• Blastoma

Cell Cycle of Antineoplastic Agents

General Toxicity of Cytotoxic Drugs

Classification of Anti-cancer Agents

• Cytotoxic Drugs
• Targeted Drugs
• Hormonal Drugs

Alkylating Agents: MOA, Resistance, Adverse Effects, Pharmacokinetics, Uses

• Nitrogen Mustard
• Ethylenimines
• Alkyl Sulfonates
• Triazine
• Nitrosoureas

Platinum Co-ordination Complex: MOA, Pharmacokinetics, Adverse Effects, Uses

• Cisplatin
• Carboplatin
• Oxaliplatin

Antimetabolites: MOA, Resistance, Drug Intercation, Adverse Effects, Pharmacokinetics, Uses

• Folate Antagonist
• Purine Antagonist
• Pyramidine Antagonist
• Vinca Alkaloids
• Taxanes
• Epipododphyllotoxin
• Camptothecin Analogue
• Antibiotics
• Miscellanoeus

Chemotherapy of Malignanacy - Part 2

Target Drugs: MOA, Adverse Effects, Pharmacokinetics, Uses

• BCR - ABL tyrosine protein kinase inhibitor
• EGF Receptor Inhibitors
• Angiogenesis Inhibitors
• Proteasome Inhibitors
• Monoclonal Antibody

Hormonal Drugs: MOA, Adverse Effects, Pharmacokinetics, Uses

• Glucocorticoids
• Estrogen
• SERMs (Selective Estrogen Receptor Modulators)
• Anti-androgens
• Aromatase Inhibitors
• 5- α Reductase Inhibitors
• GnRH Analogues
• Progestin
• SER (Selective Estrogen Receptor) Down Regulator

Treatment of Cancer