Microbial & Cellular Biology: Pathogenesis, Gene Regulation & Antimicrobial Therapies M.Pharmacy 1st Semester 2022 (2021-2022) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

M.Pharm 1st Semester exam paper covers essential topics in Microbial and Cellular Biology, blending foundational concepts with pharmaceutical relevance. Key areas include:

Core Topics Covered:

1. Cellular Mechanisms:

   • Apoptosis, oncogenesis, gene regulation (lac operon, CRISPR), and the central dogma (DNA→RNA→protein).

   • RNA processing (splicing, editing) and chromosome dynamics.

2. Microbial Systems:

   • Pathogenesis: Bacterial/viral/fungal infection mechanisms & modern therapies.

   • Industrial Applications: Microbes in drug production (e.g., penicillin, insulin).

   • Lysogeny (bacteriophages) and plasmid gene mapping (biotech tools).

3. Drug Discovery & Screening:

   • In vitro techniques for anti-tumor/anti-viral drug testing.

   • Antimicrobial agents: Mechanisms (cell wall inhibitors, DNA gyrase blockers) and resistance.

4. Comparative Microbiology:

   • Differences between eukaryotes vs. prokaryotes, bacteria vs. fungi, and actinomycetes vs. viruses.