The term antibiotit came from the rooid antibiosis: coined in 1889 by Louis pasteurs pupil paun vulttemin which means a process by life could be used to destroy life. which of
Defined as chemical substances produced by various species microrganisms such an bacteria lungs in low cone costroy or inhibit gitwith
Historical background: of
in intexander flemring discovered pencillin from the fungus Pentelllum notatum
Observed that colonies of S. aureus failed to grow in the areas contaminated by peniciltrum notatum
He isolated the mould, grelu it in a fluid medium and found that
it produced a substance capable of Eilling many of the bacteria that infect humans.
He coined the term PENICILLIN- Il was unstable and he was unable to purify.
common
* FLOREY & CHAIN Used freeze drying & chromatography to isolate penicillin & shared the Noble prize with fleming. In June 1948 pencillin was available to treat to patients
niter fermentation research 2.3 million doses had been increased in us On medium of corn steep liquor ta by product of starch manufacture),
yeast extract and others substrates added to fermenter. ofter 40 hours penicillin begins to be secreted by the fungus. The mould mycellium (cell mattest is filtered from the harvested product
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