COX1 AND COX 2 inhibitors M.Pharmacy 1st Semester 2022 (2021-2022) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

This comprehensive document explores cyclooxygenase (COX) enzymes and their inhibitors, focusing on COX-1 and COX-2 in inflammation, pain, and fever. Submitted by an M.Pharm student, it covers:

• Introduction to COX enzymes and their role in prostaglandin synthesis.

• History of COX discovery (COX-1, COX-2, COX-3).

• Classification of NSAIDs:

  • Non-selective COX inhibitors (Aspirin, Ibuprofen, Diclofenac).

  • Preferential COX-2 inhibitors (Nimesulide, Meloxicam).

  • Selective COX-2 inhibitors (Celecoxib, Etoricoxib).

• Mechanisms of action, structure-activity relationships (SAR), and synthetic pathways for key drugs (e.g., Aspirin, Paracetamol, Ketorolac).

• Clinical uses and side effects of COX inhibitors.