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BP302T PYP UNIT V pH, Buffers and Isotonic solutions 3rd Semester B.Pharmacy Lecture Notes,BP302T Physical Pharmaceutics I,

BP302T PYP UNIT V pH, Buffers and Isotonic solutions

B.Pharmacy, 3rd Semester, 2024 (2023-2024) - Lecture Notes

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59 3 Report May 30, 2024

BP302T PYP UNIT V pH, Buffers and Isotonic solutions B.Pharmacy 3rd Semester 2024 (2023-2024) Previous Year's Question Papers/Notes Download - HK Technical PGIMS



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BP302T PYP UNIT V pH, Buffers and Isotonic solutions

Sorenson’s pH scale

Applications:
The pH of the solutions must be controlled in pharmacy particularly in formulations of eye
drops, ear drops, injections and liquid orals for the following reasons
1. Enhancing Solubility and Stability
2. Improving Purity
3. Absorption of Drugs
4. Optimising Biological Activity
5. Comforting the Body
6. Storage of Products

The pH Indicators

Universal Indicator

Measurement pH

Colorimetric method

  • Principle
  • Method
  • Precautions
  • Advantages
  • Disadvantages

Electrometric method

  • Principle
  • Method
  • Precautions
  • Advantages
  • Disadvantages

Application of Buffer, Buffere Equation, Buffer Capacity, Buffer in Pharmaceutical and Biological System

Buffers

Buffer Action

Buffer Capacity

Applications of Buffer

  • Solubility Enhancement
  • Increasing Stability
  • Improving Purity
  • Optimising Biological Activity
  • Comforting the Body

Buffer system

Mechanism of Buffer action

Buffer equation-Henderson-Hasselbalch equation

Applications

Buffer Capacity

Buffers in Biological Systems

BUFFERED ISOTONIC SOLUTION 

Application

Preparation of Isotonic Buffer Solution

Osmosis- Osmotic Pressure

Applications

Iso-osmotic Solutions

Isotonic Solutions

Hypertonic Solution

Hypotonic Solution

Measurement of Tonicity

Methods of Adjusting Tonicity

Cryoscopic Method of Adjusting the Tonicity

Sodium Chloride Equivalent Method

 

 

 

 

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