Adverse Drug Reaction (U-I) B.Pharmacy 7th Semester 2025 (2024-2025) Previous Year's Question Papers/Notes Download - HK Technical PGIMS

Adverse Drug Reaction

Definition

Reasons or Causes of ADR

Classification

• Predictable
  • Excessive Pharmacologocal Activity
  • Secondary Pharmacological Effect
  • Toxicity Following Sudden Withdrawal Drug
• Unpredictable
  • Allergic Drug Reaction
  • Idiosyncracy
  • Genetically Determined Toxicity

Drug Interaction

• Pharmacokinetic Interaction
  • GIT Alteration
    • pH Change
    • Complexation
  • Distribution Alteration
    • Displacement of Protein Binding
  • Metabolism Alteration
    • Stimulation
    • Inhibition
  • Excretion Alteration
    • Urinary pH Change
• Pharmacodynamic Interaction

Beneficial Interaction

Adverse Interaction

Methods of Detecting ADR and their Management

• Case Control Studies
• Cohort Studies
• Spontaneous Case Report and Record Linkage System

Prevention of ADR

ADR Reporting and Management

• Management
  • Literature Review
  • Patient Medication Hisory Interview
  • Drug Level Studies
  • Therapeutic Decision Making